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An Experimental Study

COBB PILCHER, M.D.; WILLIAM F. MEACHAM, M.D.; EDWARD R. SMITH, M.S.

Arch Intern Med. 1947;79(4):465-472.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1945 Johnson and Walker¹ reported the death of a hydrocephalic child into whose cerebral ventricles large amounts of penicillin had been injected for treatment of an infectious condition. In this child status epilepticus had developed after administration of penicillin. This observation led Walker and his associates to carry out experimental studies² in which they demonstrated that penicillin may produce convulsions when brought into contact with cerebral tissue under a variety of conditions and in several species of animals.

A similar investigation has been made in our laboratory, and it is the purpose of this paper to present its results.

METHODS AND RESULTS

Dogs weighing 7 to 12 Kg. were used in all experiments. When operative procedures were involved, they were carried out with the animals under anesthesia induced by intravenous administration of pentobarbital sodium as separate procedures. Administration of penicillin was done on another day and without . . . [Full Text PDF of this Article]

Author Affiliations
NASHVILLE, TENN.

From the Department of Surgery, Vanderbilt University School of Medicine.

Footnotes
Part of the work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the Vanderbilt University School of Medicine, and was partly aided by the Jack Fies Fund for Research in Neurosurgery.

The penicillin was furnished by Commercial Solvents Corporation, Lederle Laboratories, Inc., Merck & Company, Inc., and E. R. Squibb & Sons, at the direction of the Committee on Chemotherapeutic and Other Agents of the National Research Council.

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