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Active Immunization Against Pneumonia with Pneumococcus Polysaccharide; Results of a Six Year Study

PAUL KAUFMAN, M.D.

Arch Intern Med. 1947;79(5):518-531.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EVER since the discovery of the causative agent of pneumonia, its high toll of death has stimulated studies on active immunization against this disease. The experiments, however, when done on human beings were always of short terms. It seemed, therefore, that there was a need for a long term experiment on active immunization against pneumonia. The year by year fluctuations in the incidence and mortality rates might have distorted the results of even the most carefully controlled immunization studies if carried on only for a short period. The perusal of the literature proves that this is exactly what happened; all these experiments, whether done on a large or small scale with vaccines or pneumococcus polysaccharides, were conducted only for one or two years. This is one of the reasons why they contain such contradictory results, contradictory sometimes even within the scope of the same experiment.

Furthermore, it seemed evident from . . . [Full Text PDF of this Article]

Author Affiliations
Attending Physician, Goldwater Memorial Hospital and New York City Home With the Technical Assistance of A. KAEFELY, M.D., Bacteriologist; S. K. KLING, M.D., Volunteer Research Worker; C. O'BRIEN, M.D., Resident Physician, and H. STEIN, M.D., Resident Physician, New York City Home; NEW YORK

From the II Medical Division of Goldwater Memorial Hospital and from the pathologic and medical divisions of the former Central and Neurological Hospital.

Footnotes
The pneumococcus polysaccharide used in the latter part of this study was supplied by Dr. Lloyd D. Felton, Medical Director, National Institute of Health, United States Public Health Service, Bethesda, Md.

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