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A Study of Thirty-One Cases

ROBERT M. HOYNE, M.D.; JAMES W. KERNOHAN, M.D.

Arch Intern Med. 1947;79(5):532-554.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PRIMARY carcinoma of the liver is a rare disease. In 1926 Counseller and McIndoe¹ reported 5 instances of this condition in 5.976 necropsies at the Mayo Clinic, and shortly thereafter they reported another.² Since that time, 25 additional cases of primary malignant growth of the liver have been discovered at necropsy at the Mayo Clinic. The present study is concerned with these 31 cases. Rokitansky³ is credited with being one of the earliest investigators to insist that a primary malignant hepatic neoplasm could occur. In 1876 Kelsh and Kiener⁴ reported 2 cases of primary carcinoma of the liver and found only 1 other case in the literature. In 1881 Sabourin⁵ added

HISTORIC SURVEY

4 more cases. In 1888 Hanot and Gilbert⁶ classified the tumors into three macroscopic groups: (1) cancer nodulaire, (2) cancer massif and (3) cancer avec cirrhose. They also suggested the microscopic . . . [Full Text PDF of this Article]

Author Affiliations
Fellow in Medicine, Mayo Foundation; ROCHESTER, MINN.

Dr. Kernohan is from the Section on Pathologic Anatomy, Mayo Clinic.

Footnotes
An abridgment of this thesis has been submitted by Dr. Hoyne to the faculty of the Graduate School of the University of Minnesota in partial fulfilment of the requirements for the degree of M. S. in Medicine.

We have included only the cases in which the primary carcinomatous growth could be localized definitely within the hepatic substance proper, as arising either from hepatic cells or from the small biliary capillaries. We have excluded any tumors arising from a hepatic duct, either external to the liver, at the porta hepatis or in the short course of this duct within the anatomic confines of the liver itself. We believe that such tumors properly should be classified as "primary carcinomas of the hepatic duct."

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