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BURTON LEVINE, M.D.; W. HAROLD CIVIN, M.D.

Arch Intern Med. 1947;80(1):53-60.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TWO ETIOLOGIC agents for rat bite fever have been described¹— Spirillum minus and Streptobacillus moniliformis.

The clinical picture can be caused not only by the bites of rats and other animals² but by the ingestion of infectious material. The Haverhill outbreak of 1926 illustrates the latter mode of infection. In 86 cases reported by Place, Sutton and Willner³ the disease was traced to the ingestion of unpasteurized milk and ice cream from a single source Parker and Hudson⁴ isolated Str. moniliformis from the blood in 11 of these cases. In their review, Brown and Nunemaker^1d further stressed the frequency of Str. moniliformis as the etiologic agent in rat bite fever.

Treatment of this disease, until recent years, was limited to the use of arsenicals, gold salts and sulfonamide compounds. The last two have been of no value. The use of neoarsphenamine and oxophenarsine hydrochloride has given apparently . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Division of Bacteriology of the Laboratories and the First Medical Service, the Mount Sinai Hospital, New York.

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