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QUIN B. DeMARSH, M.D.; HOWARD L. ALT, M.D.

Arch Intern Med. 1947;80(2):257-264.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

JAUNDICE was first recognized as a complication of infectious mononucleosis by Mackey and Wakefield in 1926.¹ A single case in which a patient with this disease exhibited jaundice had been noted previously by Downey and McKinlay.² The incidence of jaundice in different reported series of cases of infectious mononucleosis has varied from 1.3 to 12.8 per cent.³ At first, it was postulated that jaundice was due to blocking of the common duct by enlarged lymph glands.⁴ Later evidence acquired by tests of hepatic function⁵ and by biopsies of material obtained with the punch⁶ indicates that jaundice is secondary to parenchymatous changes in the liver. From a single biopsy of the liver, Kilham and Steigman^6a described a well defined focal acute hepatitis. They said: "the maximum change is seen in the portal tracts of the lobules where there is loss of liver cells and a well developed histiocytic . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Medicine, Northwestern University Medical School. School.

Footnotes
Aided by a grant from Armour and Company.

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