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Report of Two Cases

MILO D. LEAVITT, M.D.; CLIFFORD F. GASTINEAU, M.D.

Arch Intern Med. 1947;80(2):271-280.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INTRODUCTION

Antigenic Nature of Insulin.

—Insulin has been proved to be a complete and soluble protein, and like other proteins¹ it may act as an antigen. Precipitins and complement fixation antibodies probably are formed in the susceptible organism after the injection of insulin,² but this opinion is not universally accepted. Reagins (circulating antibodies responsible for dermal reactions) frequently can be demonstrated in persons sensitive to insulin by passive transfer.²

Chemists have been unable to find any difference in the microscopic appearances, isoelectric points, solubilities and molecular formulas of crystalline insulins from such varying sources as the ox, sheep, hogs and fish.³ Some workers have maintained that the insulin derived from the pancreases of human beings, cattle, hogs, sheep, bison and dogs has an immunologic identity.⁴ Other immunologists have found that beef and pork insulins have antigenic activity in common and also have a "residuum of . . . [Full Text PDF of this Article]

Author Affiliations
Fellow in Medicine, Mayo Foundation; Fellow in Medicine, Mayo Foundation ROCHESTER, MINN.

Footnotes
This work was done under the direction of Dr. C. F. Code and Dr. R. M. Wilder, with the cooperation of Dr. William Locke.

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