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Early Reactions to Administration

HAROLD A. TUCKER, M.D.; THOMAS W. FARMER, M.D.

Arch Intern Med. 1947;80(3):322-327.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A FULL evaluation of the results of penicillin therapy in cardiovascular syphilis will require observations on treated patients over a period of many years. At present, it is possible to analyze only the early reactions to administration of penicillin.

In early syphilis¹ and in neurosyphilis² the Jarisch-Herxheimer reaction ("therapeutic shock") is a frequent immediate effect of penicillin therapy. This phenomenon is of potential importance in cardiovascular syphilis because of the theoretic possibility of the occlusion of the coronary orifices or of the rupture of an aneurysm.

Moore^1a has advised that in the treatment of cardiovascular syphilis with penicillin "extreme caution should be exercised to avoid therapeutic shock within the first few days of treatment." This warning is based on 4 cases reported in the literature. Dolkhart and Schwemlein³ described 2 cases in which injection of penicillin was discontinued because of severe angina, which they attributed to . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

Footnotes
Read in abstract at the symposium, Recent Advances in the Investigation of Venereal Diseases, held on April 17, 1947, in Washington, D. C., under the auspices of the Syphilis Study Section of the National Institute of Health.

This work was performed under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the Johns Hopkins University School of Medicine and United States Public Health Service Venereal Disease Research and Post-Graduate Training Center and under a grant-in-aid from the Research Grants Office, National Institute of Health, United States Public Health Service.

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