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A Study of Five Generations

LIEUTENANT CAL S. KELLOGG

Arch Intern Med. 1947;80(3):358-365.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PURPOSE of this paper is to report a family in which five generations have been affected with osteogenesis imperfecta. Riesenman and Yater,¹ after a study of seven families, concluded that osteogenesis imperfecta (fragilitas osseum, Lobstein's disease or Vrolik's disease) is "a hereditary and familial disease and is transmitted as a dominant mendelian factor. It is a hereditary mesenchymal hypoplasia due to a disturbance of the gene or genes that determine normal mesenchymal development."

Lobstein is generally given credit for first describing this disease, but Riesenman and Yater¹ ascribed the first description to Elman in 1788. Lobstein's syndrome today is called osteogenesis imperfecta tarda in contradistinction to the syndrome described by Vrolik in 1849. The latter, at present, is referred to as the early or congenital form. Spurway² in 1896 called attention to the fact that certain patients with fragile bones also had blue scleras. Bronson³ . . . [Full Text PDF of this Article]

Author Affiliations
MEDICAL CORPS, UNITED STATES NAVAL RESERVE

From the Department of Medicine, Toledo Hospital.

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