This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (10)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Treatment With the Histamine Antagonists

SANDER PAUL KLEIN, M.D.

Arch Intern Med. 1948;81(3):316-327.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INCIDENCE OF INSULIN ALLERGY

INSULIN allergy, the antigenic response to the insulin protein, is a rare but important occurrence in diabetic management. The incidence of allergic reactions to insulin varies widely in the reports in the literature. Some observers considered mild local reactions as allergic manifestations. Others were found to exclude all local reactions regardless of severity and to designate as allergic only those patients for whom insulin therapy had to be discontinued. Hence such wide variations as Grafe's¹ 0.15 per cent, Collens'² 7.3 per cent and Allan and Scherer's³ 11.7 per cent were reported. Of persons sensitive to insulin, Allan and Scherer estimate that from 98 to 99 per cent will show a reaction limited to the site of injection while only 1 or 2 per cent will exhibit general or systemic manifestations. Thus, approximately one in a thousand using insulin will have a generalized reaction.

Mild local reactions . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Fifth and Sixth (Boston University) Medical Services, Boston City Hospital.

Footnotes
Dr. Klein is a resident at the Boston City Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?