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Review of the Literature

MONROE COHEN, M.D.

Arch Intern Med. 1948;81(6):879-887.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Before the discovery of potent adrenal cortex preparations, the maternal mortality in Addison's disease complicated by pregnancy was 35 per cent among the 20 reported cases. Some case reports are brief, but in most instances the diagnosis of adrenal disease was proved at autopsy Therapeutic abortions were uniformly fatal, and one third of the fetuses died at term delivery.¹

From 1930 to 1939, 8 cases, with a 25 per cent mortality, were reported. In 4 cases the pregnancies went to term and the patients survived, and in 2 cases therapeutic abortions were successful. Uncontrollable vomiting leading to adrenal crisis caused the death of 1 patient in the second month of pregnancy, and premature labor terminated in the death of another.²

Since 1940 there were 15 reported cases, and 7 more have been available to us for study. In 18 of the 22 cases the pregnancy went to term, . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Department of Medicine, Long Island College of Medicine Division, Kings County Hospital.

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