This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (17)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

HAROLD L. HIRSH, M.D.; H. F. DOWLING, M.D.; J. A. ROBINSON, M.D.

Arch Intern Med. 1948;82(3):310-318.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT IS GENERALLY supposed that bacteria which are sensitive to the action of penicillin seldom acquire resistance to this antibiotic as a result of the treatment of human infections. In most cases of infection amenable to penicillin therapy a prompt clinical response is obtained and administration is discontinued. Generally, there is little opportunity for resistant strains to develop in such cases as the period of treatment is usually of relatively short duration.

The appearance of resistant organisms while the patient was under treatment with penicillin has been reported.¹ In most of the cases the sensitivities of the organisms had not been determined before treatment was started so that the strains may have been naturally resistant. In other cases the bacteria were isolated from open wounds and thus were exposed to contamination from outside sources, so that it is impossible to determine whether the resistant strains were derived from the organisms . . . [Full Text PDF of this Article]

Author Affiliations
WASHINGTON, D. C.

From the Georgetown and George Washington medical divisions, Gallinger Municipal Hospital, and the departments of medicine, Georgetown and George Washington universities' schools of medicine.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?