This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

MARK T. HOEKENGA, M.D.; THOMAS W. FARMER, M.D.

Arch Intern Med. 1948;82(6):611-622.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN NEUROSYPHILIS an early reaction to the administration of spirocheticidal drugs (the Jarisch-Herxheimer reaction) may take one or both of two forms: a transient rise in temperature during the first twenty-four hours after administration of the drug or an exacerbation of mental symptoms or neurologic sign during the first few days.

Febrile reactions have been observed after the administration of arsenical drugs, bismuth and, more recently, penicillin. The literature contains only brief comments concerning the incidence and severity of fever after the use of these drugs.

Symptomatic Herxheimer reactions occur not only after the administration of spirocheticidal drugs but also during fever therapy (especially induced malaria). The variety of manifestations observed is related to the type of neurosyphilis. For example, in patients with dementia paralytica there may occasionally occur exacerbations of the existing psychoses or the development of new symptoms. Confusion, agitation, hallucinations and convulsions may sometimes develop. In persons . . . [Full Text PDF of this Article]

Author Affiliations
ANCON, PANAMA CANAL ZONE; Assistant Professor of Neurology and Psychiatry, Southwestern Medical College DALLAS, TEXAS

From the Johns Hopkins University and the United States Public Health Service, Venereal Disease Research and Post-Graduate Training Center.

Footnotes
Senior medical resident, Gorgas Hospital, Canal Zone; formerly senior fellow in medicine, National Institute of Health.

Formerly senior fellow in medicine, National Institute of Health.

This work was done under a grant from the Research Grants and Fellowship Division, National Institute of Health, United States Public Health Service.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?