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ROBERT I. BOYD, M.D.

Arch Intern Med. 1949;83(3):298-304.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE is general agreement that the liver is involved in the formation of plasma proteins. The evidence is well defined in the case of fibrinogen¹ and of prothrombin,² but in the case of other globulin fractions serious question remains. The work of Whipple and his collaborators³ relates the liver to hypoalbuminemia under the conditions of their experiments. Furthermore, in the later stages of cirrhosis of the liver it has long been known that the serum albumin concentration is less than normal.⁴ A similar and often even more pronounced decrease in serum albumin concentration is seen in patients in the degenerative stage of glomerular nephritis with edema. It is not immediately apparent why this plasma anomaly should occur as a direct consequence of the renal lesion. There is agreement that mere loss of protein in the urine cannot be regarded as an adequate explanation for the . . . [Full Text PDF of this Article]

Author Affiliations
PASADENA

From the Department of Medicine, Stanford University School of Medicine, San Francisco.

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