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J. ERIK JORPES, M.D.

Arch Intern Med. 1949;83(4):363-371.

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ALLERGIC reactions from insulin can be viewed from different aspects. They causedifficulties in insulin therapy, sometimes even making a discontinuation of treatment with insulin compulsory. Of no less interest from a theoretic point of view is the question of the presence or absence of antigenic properties in insulin. As a hormone common to all vertebrate animals, insulin could be assumed to have a definite molecular structure irrespective of the species from which it derives and should not be antigenic. Nevertheless, authors who review the literature on this topic (Yasuna¹ and Watson²) tacitly accept the concept that insulin is an antigen, capable of inducing sensitization. Desensitization has consequently been considered as the last resort in cases of severe allergic reactions. Rapid (Corcoran,³ Ulrich and others⁴ and Bayer⁵) as well as prolonged (Weitz⁶) procedures for desensitization of the patients have consequently been worked out. If successful, the rapid desensitization eliminates the difficulties . . . [Full Text PDF of this Article]

Author Affiliations
STOCKHOLM, SWEDEN

From the Chemistry Department of the Caroline Institute.

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