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MORRIS E. DAILEY, M.D.; MAYO H. SOLEY, M.D.; STUART LINDSAY, M.D.

Arch Intern Med. 1949;83(4):382-389.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PURPOSE of this paper is to indicate which facts in the history and examination of a patient aid in the differential diagnosis of nontoxic nodular goiter. The nodules may be involutionary, neo-plastic or, more rarely, sites of thyroiditis. From July 1935 to July 1941, 242 patients with nontoxic nodular goiter were seen in the University of California's thyroid clinic. Sufficient data, follow-up observations and pathologic specimens were available to permit consideration of 114 cases in this study. Gross specimens and histologic sections of the glands were studied, and, with these data as a base line, an attempt was made to correlate the clinical features with the pathologic diagnosis of this condition. —The investigations of Marine¹ seem to have established that involutionary nodules in the thyroid gland are formed by cyclic hyperplasia and involution. This waxing and waning of local acinar activity and of colloid storage is

PATHOLOGIC CLASSIFICATION . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Divisions of Medicine and Pathology, University of California Medical School and the Thyroid Clinic, University of California Hospital.

Footnotes
Statistical aid was given by Dr. J. Richard Skahen and Miss Jean Hitch.

This study was aided by grants from the Donner Foundation, Cancer Research Division, Philadelphia.

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