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With Special Reference to the Effect of Supplementation with Protein or Protein Hydrolysate

MICHAEL G. WOHL, M.D.; JOHN G. REINHOLD, Ph.D.; S. BRANDT ROSE, M.D.

Arch Intern Med. 1949;83(4):402-415.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IMMUNITY is dependent in part on antibody production. There is ample evidence that antibodies are globulins modified in response to the presence of an antigen.¹ Antibody globulins, like other plasma proteins and body proteins as well, are derived from dietary protein and thus depend for their formation on protein intake adequate in quality and quantity.² Furthermore, the fundamental studies of Cannon and his co-workers³ and of others⁴ have shown that antibody production is lessened when hypoproteinemia is produced in experimental animals. Wissler and others⁵ demonstrated that protein repletion is associated with improved antibody response. The degree of protein depletion required to impair production of antibodies in animals was rather drastic in many of the experiments cited, and the relative importance of their observations as they relate to human antibody response has been challenged.⁶

Because of the clinical implications of these experimental studies, we have (1) investigated production of antibodies in . . . [Full Text PDF of this Article]

Author Affiliations
With the Assistance of L. ASHBY ADAMS, M.D.; THOMAS HARVEY, M.D.; MOSES FRANCIS, M.D., and GEORGE CLOUGH PHILADELPHIA

From the Medical Services, Division of Chemistry and Division of Bacteriology, Philadelphia General Hospital.

Footnotes
This study was made possible by a grant from the National Drug Company. Dr. Gustav Martin and Mr. Steven Horoschak contributed their interest and support.

Read before the Section on Experimental Medicine and Therapeutics at the Ninety-Seventh Annual Session of the American Medical Association, Chicago, June 1948.

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