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Clinical Implications as an Index of Adrenal Cortical Function

JEROME W. CONN, M.D.

Arch Intern Med. 1949;83(4):416-428.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DURING the past fifteen years a large number of steroid compounds have been isolated from adrenal cortices of animals. Whether the adrenal cortex during life actually secretes each of these steroids remains an unsolved problem. In more recent years it has gradually become apparent that if one classifies according to their major functional effects the various physiologically active steroids which have been derived from the adrenal gland each falls into one of three main groups:

1. Adrenal steroids possessing activities of sex hormones
   
   1. Androgenic
      
   2. Estrogenic
      
   3. Progesterone
      
   
   
2. Adrenal steroids which affect protein, carbohydrate and uric acid metabolism and which also produce important hematologic changes.
   
3. Adrenal steroids which act mainly on sodium, potassium and chloride metabolism and, thus, on water metabolism as well.
   

Author Affiliations
ANN ARBOR, MICH.

From the Department of Internal Medicine, University of Michigan Medical School.

Footnotes
This work represents part of a project financed by the Research Grants Division of the United States Public Health Service.

Read before the Section on Experimental Medicine and Therapeutics at the Ninety-Sixth Annual Session of the American Medical Association, Chicago, June 23, 1948.

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