This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Report of a Case with Autopsy

E. A. HAUNZ, M.D., M.S. (Med.)

Arch Intern Med. 1949;83(5):515-527.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INSULIN resistance is a curious clinical phenomenon, the exact etiologic mechanisms of which are as yet unknown. Since marked variations in sensitivity to insulin exist among both diabetic and nondiabetic patients, the term is popularly restricted to patients requiring 200 or more units of insulin daily to lower appreciably the blood sugar content.¹ In terms of diabetic patients, the validity of this definition is enhanced by reports that depancreatized man probably requires only 35 to 50 units daily to control adequately the resultant diabetes.²

The term "insulin insensitive"³ has been suggested to characterize those diabetic patients who require less than 200 units daily but more than usual doses for adequate control. It is of interest that insulin resistance has been encountered in nondiabetic schizophrenic patients undergoing shock therapy.⁴ This renders any theory untenable which demands the coexistence of diabetes mellitus in all cases of insulin . . . [Full Text PDF of this Article]

Author Affiliations
GRAND FORKS, N. D.

From the Department of Internal Medicine, Grand Forks Clinic.

Footnotes
Read at the Regional Meeting of the American College of Physicians at Fargo, N. D., Sept. 11, 1948.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?