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Report on Two Families, with Observations on the Pathogenesis of the Syndrome

DEWEY K. ZIEGLER, M.D.

Arch Intern Med. 1949;84(3):419-430.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TRANSIENT paralysis of skeletal muscle without other neurologic abnormality is an interesting syndrome which has been recognized and observed clinically for over a hundred years. Although in comparatively recent times the disorder has been reported in the course of other diseases, notably thyrotoxicosis,¹ and in diabetic coma,² in by far the larger number of cases reported it existed as a familial trait, unassociated with other disease.

During a typical attack, the patient shows flaccid paralysis of the skeletal musculature, loss of all deep reflexes and electrical excitability of the muscles, with complete preservation of sensation and mental function. The disease usually does not manifest itself until puberty; the attacks of paralysis are characteristically noted by patients when they awaken in the early morning hours. Weakness lasts from a few hours to a few days, spares all musculature above the neck and disappears completely without residual effects.

In 1941, . . . [Full Text PDF of this Article]

Author Affiliations
Assistant Resident, Neurological Institute of New York NEW YORK

Footnotes
The case of patient A. L. was studied in the neuropsychiatric service of the United States Naval Hospital, San Diego, Calif.

This article has been released for publication by the Division of Publications of the Bureau of Medicine and Surgery of the United States Navy. The opinions and views set forth in this article are those of the writer and are not to be construed as reflecting the policies of the Navy Department.

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