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JAKUB G. SCHLICHTER, M.D.; GEORGE D. AMROMIN, M.D.; A. J. L. SOLWAY, M.D.

Arch Intern Med. 1949;84(4):558-568.

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REPEATED attempts have been made to ascertain the underlying etiologic factors in idiopathic cystic necrosis of the aorta since it was first described by Gsell¹ and by Erdheim.² Workers have pursued several courses, among which have been the morphologic and the experimental. Among the former, the work of Erdheim is still fundamental and outstanding. He noted specifically the absence of vasa vasorum at the site of rupture in those instances in which the aorta showed the typical picture of medial necrosis. In other cases, he observed some degree of hyalinization. Despite his observations and the later work of Wiese,³ he stated the belief that the vasa vasorum did not play a role in the production of medionecrosis of the aorta. He favored the idea of some form of hyperadrenalism as the possible etiologic factor. Later workers⁴ noted alterations of the vasa vasorum.

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Author Affiliations
CHICAGO

Footnotes
This study was aided by grants from the A. D. Nast Fund for Cardiovascular Research and the Ira Frank Fund.

From the Cardiovascular and Pathology Departments, Medical Research Institute, Michael Reese Hospital. These departments are supported in part by the Michael Reese Research Foundation.

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