This Article  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Compiled by E. M. Hume and H. A. Krebs. Medical Research Council Special Report Series, No. 264. Price, 3s. Pp. 145. London: His Majesty's Stationery Office, 1949.

Arch Intern Med. 1949;84(5):839-840.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This monograph is a description of a long and complicated experimental study on 23 human volunteers, 16 of whom were given a diet virtually devoid of vitamin A and carotene; the remaining 7 received the same diet with a daily supplement of either 2,500 international units of oleovitamin A U. S. P. (natural vitamin A in oil), or 5,000 international units of carotene. The principal laboratory tests used to determine the extent of vitamin A deficiency were measurements of plasma vitamin A and carotenoid content and various tests of retinal function. The latter were the more reliable. Indisputable evidence of deficiency did not appear until after eight months; ultimately, unmistakable deficiency developed in only 3 of the 16 volunteers who persisted in the tests for twelve to twenty-four months.

Follicular hyperkeratosis, conjunctival degeneration and abnormal fatigue were not encountered. After deficiency states were observed, the amounts of vitamin A or . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?