This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (26)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Study of Thirty Affected Persons in a Family

REX M. ALVORD, M.D.

Arch Intern Med. 1949;84(6):1002-1019.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CLINICAL investigations concerning disturbances in lipid metabolism have opened a new chapter in the etiology of coronary heart disease. Recent studies have revealed an extremely high incidence of xanthomas and specific types of heart disease associated with hyperlipemia, especially hypercholesteremia.

The earlier investigators were concerned mainly with the etiology of xanthomatous lesions of the skin and tendons. These deposits have long been considered medical curiosities, and even today little is known concerning their formation. Tuberous xanthomas were first described by Addison and Gull,¹ in 1851, but it was not until 1920 that Chauffard. Laroche and Grigaut² and Burns³ demonstrated that there was an increased amount of total serum cholesterol in patients with xanthomas. In 1929, Wile, Eckstein and Curtis⁴ stated that the formation of xanthomas could not be explained solely by the theory of hypercholesteremia and that a defect in fat metabolism, in which cholesterol undoubtedly . . . [Full Text PDF of this Article]

Author Affiliations
SALT LAKE CITY

From the Department of Pathology, Stanford University School of Medicine, San Francisco.

Footnotes
Dr. Alvord is now in the Department of Medicine, University of Utah College of Medicine, Salt Lake City.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?