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PHILIP KRAININ, M.D.; CARL J. D'ANGIO, M.D.; AMMIEL SMELIN, M.D.

Arch Intern Med. 1949;84(6):976-982.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE that the typical and characteristic lesion of bone in multiple myeloma is a discrete osteolytic involvement. The roentgenographic appearance is usually that of a punched-out area with sharp margination and without evidence of surrounding productive reaction. In a description of multiple myeloma Boyd¹ stated, "It is a pure rarefying lesion with no formation of new bone." To quote Geschichter²: "The widespread occurrence of small, sharply demarcated defects in the marrow cavity, unaccompanied by bending deformity or the formation of new bone, are the cardinal features in the diagnosis of multiple myeloma." Snapper³ affirmed that in multiple myeloma "no new formation of bone takes place." Shanks, Kerley and Twining⁴ declared categorically concerning the osseous lesions of multiple myeloma that "they are entirely osteolytic, and never give rise to new bone formation."

The case to be presented is of unusual interest because it has been possible to . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Medical Service, Dr. S. Biloon, Director, Dr. William Aronson, Pathologist, and Dr. Samuel Weitzner, Radiologist, Morrisania City Hospital.

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