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USE OF LITHIUM SALTS AS A SUBSTITUTE FOR SODIUM CHLORIDE
JOHN H. TALBOTT, M.D.
Arch Intern Med. 1950;85(1):1-10.
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MY INTEREST in lithium salts and independently in substitutes for sodium chloride dates back to the early 1930's, when the acidbase balance of patients with various metabolic disorders was under investigation. There were at least two aspects to this study. First, attention was centered on the sodium fraction1 of body fluids. Since this ion accounts for approximately 90 per cent of inorganic base in serum and extracellular fluid, it was considered desirable in one phase of the investigation to maintain normal and sick persons on a diet as low in sodium chloride as possible, meanwhile making the food palatable on a constant dietary intake. A constant diet suitable for metabolic studies usually is monotonous, and when the content of sodium chloride is greatly reduced it becomes a difficult matter to accomplish the desired aim. A casual search was made for a satisfactory substitute to replace the salty taste of
. . . [Full Text PDF of this Article]
Author Affiliations
BUFFALO
From the Departments of Medicine, University of Buffalo School of Medicine and Buffalo General Hospital.
Footnotes
Read before the Section on Experimental Medicine and Therapeutics at the Ninety-Eighth Annual Session of the American Medical Association, Atlantic City, N. J., June 9, 1949.
The researches of the laboratory in which these studies were made were supported in part by a grant from Mrs. Kathleen Stevens Chard, Cazenovia, N. Y., in memory of her mother, Mrs. Hattie Brooks Stevens, formerly of Buffalo.
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