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A Review of the Recent Literature

HERMAN BEERMAN, M.D.; LESLIE NICHOLAS, M.D.; MINERVA S. BUERK, M.D.; WILLIAM T. FORD, M.D.

Arch Intern Med. 1950;85(4):699-721.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Radioactive Penicillin.

—After parenteral administration of penicillin, up to 70 per cent of the drug is excreted unchanged in the urine. In order to determine the fate of the remainder of the penicillin and the excretion path of penicillin after intramuscular and oral administration, Rowlands and his co-workers¹⁸² made urinary excretion studies in female cats, using radioactive penicillin (penicillin containing the radioactive sulfur isotope S³⁵). The radioactivity of the urines was calculated as "Geiger-penicillin units" on the basis that 1,100 disintegrations a minute are equivalent to 1 unit of penicillin. Nonpenicillin radioactivity was calculated by subtracting the biologic penicillin level from the Geiger penicillin level. Results demonstrated that after intramuscular injection of labeled penicillin, 72 to 101 per cent of Geiger penicillin was recovered in the urine and only 36 to 66 per cent of biologic penicillin. The authors state that the difference between . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

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