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M. D. ALTSCHULE, M.D.; BARBARA H. PARKHURST, B.S.; ELAINE PROMISEL

Arch Intern Med. 1950;86(4):505-518.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE OBSERVATIONS of Dougherty and White¹ on the effects of pituitary adrenocorticotropic hormone on lymphoid tissue led these authors to review some of the earlier work on changes which occurred in the lymphocyte count in infections or after the injection of bacterial toxins; Dougherty and White¹ concluded that the lymphopenia caused by bacterial toxins was a consequence of the action of adrenal cortex hormones. More recently, however, Lewis and Page² cast doubt on this concept when they showed that adrenalectomy does not prevent the decrease in the number of blood lymphocytes which results from the injection of typhoid vaccine. On the other hand, there is histologic evidence that reactions to the injection of bacterial vaccines are associated with the same changes in the adrenal gland as are other forms of stress.³ In view of these discrepancies, it was considered of

interest to make studies of the blood leukocytes and of . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Laboratory of Clinical Physiology, McLean Hospital, Waverley, Mass., and the Department of Medicine, Harvard Medical School, Boston.