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CHRONIC RECURRENT NONHEMOLYTIC STREPTOCOCCIC ENDOCARDITISReport of a Patient Treated Concurrently with Penicillin and Dihydrostreptomycin
WILLIAM C. ROBBINS, M.D.;
RALPH TOMPSETT, M.D.
Arch Intern Med. 1950;86(4):578-584.
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Relapse of subacute bacterial endocarditis following penicillin therapy has been observed in some patients with all dosage regimens thus far adopted for general use. A significant reduction in the frequency of relapse has been accomplished in recent years by employing larger doses of penicillin and by extending the duration of treatment to six or more weeks. The refractory cases now encountered are frequently those in which the infection is caused by organisms highly resistant to penicillin, notably enterococci. In other cases, in which the organisms are quite sensitive to penicillin in vitro, relapse following the administration of penicillin is not readily attributable to a property of the infecting bacterial population but is generally ascribed to the nature of the lesion or to a deficiency in the resistance mechanisms of the particular host.
Recent observations on the combined action of penicillin and streptomycin on Enterococcus in vitro, together with the favorable
. . . [Full Text PDF of this Article]
Author Affiliations
Postdoctorate Research Fellow in Medicine, National Institutes of Health, United States Public Health Service; NEW YORK
From the Department of Medicine, The New York Hospital—Cornell Medical Center.
Footnotes
This study was aided in part by grants from The Division of Research Grants and Fellowships of the National Institutes of Health, United States Public Health Service; Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y., and Chas. Pfizer & Company, Inc., Brooklyn.
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