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Evaluation of Some Drugs in Seasickness

MAJOR HERMAN I. CHINN; WERNER K. NOELL, M.D.; LIEUTENANT COLONEL PAUL K. SMITH

Arch Intern Med. 1950;86(6):810-822.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MOTION sickness represents a response to a particular pattern of vestibular discharges which are generated chiefly in the utriculus of the labyrinth and stimulate pathways through the cerebellum to the brain stem.¹ The response requires a lengthy process of summation since minutes to hours are needed until the vestibular discharges induce a variety of symptoms which culminate in vomiting. Conversely, a relatively rapid process of adaptation may suppress the manifestations of motion sickness. In addition, there are other ways of weakening or preventing the response. Thus, the effect of motion is minimized by assuming a supine position, which greatly reduces the stimulation of the utriculus. Further, the reduction of psychological, visual, visceral or other facilitating influences may lower the incidence of motion sickness. Finally, there are certain drugs which are preventive.

During World War II extensive investigations centered on parasympatholytic agents, central nervous system stimulants or depressants, vitamins or . . . [Full Text PDF of this Article]

Author Affiliations
MEDICAL SERVICE CORPS, UNITED STATES AIR FORCE; RANDOLPH FIELD, TEXAS; UNITED STATES AIR FORCE

Footnotes
From the Departments of Pharmacology and Biochemistry and of Neuropsychiatry, United States Air Force School of Aviation Medicine, Randolph Field, Texas, and the Department of Pharmacology, George Washington University School of Medicine, Washington, D. C. The following persons contributed largely to this study: Sgt. H. Midkiff, of the School of Aviation Medicine, supervised many of the technical aspects; Col. W. E. Stone, M.C., Surgeon General's Office, United States Army, procured the ship and subjects; Lieut. Col. R. E. Blount, M.C., Surgeon General's Office, United States Air Force, coordinated all administrative matters; Col. Pfeffer, M.C., Port Surgeon, and Capt. D. J. Cracovner, (M.C.) U. S. N., of the New York Port of Embarkation, supplied personnel to assist us during the journey; Capt. Boysen, M.C., Lieut. (jg) W. D. Reese and Lieut. (jg) R. J. Walther, Medical Officers aboard ship, gave medical supervision; Lieut. Col. J. R. Hess, Transport Commander, assisted with the troops; Sgt. H. S. Orff, Cpl. J. W. Cromer, Pfc. H. F. Lauder, Hospital Mates D. H. O'Connell, J. R. Salisbury, G. W. Behrle, D. J. Fleming and L. F. McCabe gave technical assistance, and Mr. A. Kimball, Capt. W. L. Dixson and Mr. T. J. Stewart made the statistical evaluations.

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