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LIVER DYSFUNCTION FOLLOWING ABDOMINAL OPERATIONSThe Significance of Postoperative Hyperbilirubinemia
WILLIAM GELLER, M.D.;
HENRY J. TAGNON, M.D.
Arch Intern Med. 1950;86(6):908-916.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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SEVERAL reports in the literature deal with the effect of surgical operations on liver function.1 The hippuric acid and sulfobromophthalein (bromsulphalein®) sodium tests have been used in several studies. Tagnon, Robbins and Nichols2 reported changes in the sulfobromophthalein clearance following extra-abdominal operations. In their series of patients there was no consistent postoperative alteration in the thymol turbidity or cephalin flocculation reactions.
The work reported below describes the effect of abdominal operation on the sulfobromophthalein clearance, cephalin flocculation and thymol turbidity. Abnormalities of the two former reactions were observed in a high proportion of the cases reported here. In addition, since sulfobromophthalein clearance parallels bilirubin clearance in dogs,3 an attempt was made to correlate the incidence of postoperative hyperbilirubinemia in this series of patients with the impairment of the sulfobromophthalein clearance.
MATERIAL AND METHODS
The observations were made on patients admitted to the surgical services at Memorial
. . . [Full Text PDF of this Article]
Author Affiliations
Assistant Resident in Medicine; Associate Attending Physician, Memorial Hospital; Associate, Sloan-Kettering Institute; Assistant Professor of Clinical Medicine, Cornell University Medical School; NEW YORK
From the Department of Medicine, Memorial Center, New York City.
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