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II. Physiology

LEONARD C. MOLOFSKY, M.D.; FRANKLIN HOLLANDER, Ph.D.

AMA Arch Intern Med. 1951;87(1):110-123.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WHATEVER may be the ultimate cause of pernicious anemia, a review of the literature on the pathological aspects of this disease¹ reveals a serious degree of gross and microscopic alteration in the stomach. As a result of these morbid changes, extensive alterations in physiological processes naturally occur. Of all the gastric functions, it is the secretion which has been most frequently studied in relation to the pathogenesis of the disease and which is most seriously impaired.

VOLUME OF GASTRIC JUICE

Fenwick² first called attention to a deficiency in gastric secretion in patients with pernicious anemia (hereafter written P.A.). However, as in other early work, he used the term "achylia gastrica" merely to indicate an absence or decrease in volume of secretion without further qualification. Since then the striking deficiency in the total amount of gastric juice has been confirmed by many other investigators. Thus, Wintrobe³ could collect . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Gastroenterology Research Laboratory, The Mount Sinai Hospital.

Footnotes
Postgraduate student in gastroenterology, 1947.

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