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Its Occurrence in Fifteen Patients Who Did Not Receive Directed Therapy

NORMAN M. KEITH, M.D.; HENRY P. WAGENER, M.D.

AMA Arch Intern Med. 1951;87(1):25-47.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WE DESCRIBED in 1924¹ a clinical syndrome that occurred in a small group of patients who had had severe hypertension and neuroretinopathy. The further course of the disease was progressive, often rapidly fatal, and led us to apply the term syndrome of malignant hypertension to the condition. Our clinical and pathological studies suggested that the widespread involvement of many viscera was due to diffuse alterations in the arteriolar system.² With increasing experience in subsequent cases, we 3 and others⁴ on rare occasions observed a patient in whom the disease appeared to be arrested and recession of the papilledema and of the retinopathy had occurred. Over a period of 20 years, we have seen the subsidence of the retinopathy in 15 patients and at the time of the observation were unable to offer a satisfactory explanation for this favorable turn of events.

Other investigators have reported recession of . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

From the Division of Medicine (Dr. Keith) and the Section on Ophthalmology (Dr. Wagener), Mayo Clinic.