This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

II. Experimental Observations

C. A. SCHAFFENBURG, M.D.; J. B. R. McKENDRY, M.D.; E. PERRY McCULLAGH, M.D.

AMA Arch Intern Med. 1951;87(2):199-203.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN NOVEMBER 1949, Lewin and Wassén¹ reported beneficial effects from the use of combined desoxycorticosterone acetate and ascorbic acid in treatment of rheumatoid arthritis. The numerous contradictory reports since that time have been reviewed in the preceding article,² in which we attempted to evaluate this treatment in rheumatoid arthritis.

The present communication concerns a study in experimental animals of the effects of concurrent administration of desoxycorticosterone acetate and ascorbic acid. It is known that chronic overdosage with this hormone in the rat leads to development of typical lesions in the heart, kidneys and arteries, with elevation of arterial blood pressure,³ and under certain experimental conditions to development of arthritis.⁴ Recently. Selye⁵ has reported the aggravation of formaldehydeinduced "arthritis" in rats by use of desoxycorticosterone acetate and its prevention or cure by administration of cortisone or pituitary adrenocorticotropic hormone

(ACTH). Brownlee,⁶ using Selye's technic, reported beneficial . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Cleveland Clinic and the Frank E. Bunts Educational Institute.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?