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STUDIES ON ANTIBIOTIC SYNERGISM AND ANTAGONISMThe Interference of Chloramphenicol with the Action of Penicillin
E. JAWETZ, M.D., Ph.D.;
J. B. GUNNISON, M.A.;
R. S. SPECK, M.D.;
V. R. COLEMAN, B.A.
AMA Arch Intern Med. 1951;87(3):349-359.
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THE DYNAMICS of antimicrobial action are known to some extent for the "older" antibiotics, particularly penicillin. Data are being accumulated at present on the "newer" antibiotics, aureomycin, chloramphenicol and terramycin. Relatively little information, however, is available on the results of simultaneous action of two or more antibiotics. Such basic information is desirable particularly in view of the increasing trend for multiple antibiotic therapy in medical practice.
Two antibiotics acting simultaneously might be additive, synergistic, antagonistic or without any effect on each other. This spectrum of possible combinations has been shown to exist for various sulfonamides1 and has been suggested for antibiotics.2 Synergistic effects have been demonstrated for combinations of penicillin and streptomycin in their action against enterococci in vitro3 and against enterococcic human infections.4 In some other infections (e. g., brucellosis) it has also been shown that combinations of antibiotics can achieve results unobtainable with any
. . . [Full Text PDF of this Article]
Author Affiliations
SAN FRANCISCO
From the Division of Bacteriology, University of California School of Medicine.
Footnotes
This study was supported in part by a grant from the Research Committee of the University of California School of Medicine.
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