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ANTISTREPTOLYSIN O RESPONSE FOLLOWING HEMOLYTIC STREPTOCOCCUS INFECTION IN EARLY CHILDHOOD
LOWELL A. RANTZ, M.D.;
MARGARET MARONEY, M.D.;
JOSEPH M. DI CAPRIO, M.D.
AMA Arch Intern Med. 1951;87(3):360-371.
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HEMOLYTIC Streptococcus infections in humans beings have been intensively studied during the last 20 years particularly because of the intimate association of these disorders with acute rheumatic fever.1 The subjects of nearly all these investigations have been in one of two categories. One group has been composed of persons, usually children, in whom the rheumatic state or acute nephritis was already established.2 The other has consisted of young adults, often military personnel, in whom detailed analyses of the natural history of acute streptococcic respiratory infection and its nonsuppurative sequelae have been made.3
Surprisingly few studies have been made of the course and associated immunologic phenomena in group A Streptococcus infection in nonrheumatic infants and children, although the diseases caused by these organisms are unusual in civilian life in any age groups but these. Most important has been the report of Powers and Boisvert,4 which clearly defined the changing pattern of
. . . [Full Text PDF of this Article]
Author Affiliations
SAN FRANCISCO
From the Departments of Medicine and Pediatrics, Stanford University School of Medicine, San Francisco.
Footnotes
This investigation was conducted under the auspices of the Commission on Acute Respiratory Diseases, Armed Forces Epidemiological Board, aided by a grant from the Life Insurance Medical Research Fund, and supported in part by a research grant from the National Heart Institute of the National Institutes of Health, United States Public Health Service.
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