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ARTHUR GROLLMAN, Ph.D., M.D.; LOUIS B. TURNER, M.D.; JAMES A. McLEAN, M.D.

AMA Arch Intern Med. 1951;87(3):379-390.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PREVIOUS studies on the use of artificial measures (the artificial kidney, exchange blood transfusions, peritoneal lavage, etc.) to maintain life in the absence of renal function have been carried out chiefly on the human patient. Thus, a total of 101 patients have been treated by continuous peritoneal lavage,¹ but the value of the method remains equivocal because many patients with acute anuria recover spontaneously when treated by more conservative measures.² It was deemed necessary, therefore, to carry out studies on the nephrectomized animal in order to establish the potentialities of the method before proceeding to its application to the human patient.

The present paper describes procedures for performing peritoneal lavage, by means of which it has been possible to maintain bilaterally nephrectomized dogs for periods of 30 to 70 days, which is several times that ever reported previously. With consideration of the inevitable malignant hypertension that develops following . . . [Full Text PDF of this Article]

Author Affiliations
With the Technical Assistance of Maurine Giese, William M. Ott and Gordon M. Gafford DALLAS, TEXAS

From the Department of Experimental Medicine, Southwestern Medical School of the University of Texas.

Footnotes
This investigation was supported by a grant from the Medical Insurance Research Fund.

Dr. Grollman is Professor of Experimental Medicine, Southwestern Medical School of the University of Texas, and Attending Physician, Parkland Hospital. Dr. Turner is Fellow of the Dazian Foundation for Medical Research. Dr. McLean is Research Fellow in Experimental Medicine.

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