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Response to Therapy

MENDEL KRIM, M.D.; ARTHUR SAWITSKY, M.D.; DAVID KROHN, M.D.; LEO M. MEYER, M.D.

AMA Arch Intern Med. 1951;87(3):418-423.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DIAGNOSIS of Gaucher's disease (lipid histiocytosis of kerasin type) is made on the basis of the following typical findings: hepatosplenomegaly, wedge-shaped pingueculae in the conjunctivas, pigmentation on the lower part of the legs, bone lesions which tend to occur in the head, neck and lower end of the femurs and a normal blood cholesterol level. Most usually there are hypochromic anemia, leukopenia and thrombocytopenia. The diagnosis is made conclusive by demonstration of typical Gaucher cells, and this is easily done by sternal marrow aspiration.¹

Potter and McRae described a case of Gaucher's disease treated with liver extract.² Their patient was admitted with hypochromic anemia. No bone marrow studies were made. Because of macrocytosis, the patient received 3 to 4 vials of liver extract daily for 11 months. There was symptomatic improvement, and a decrease in skin pigmentation, pingueculae and spleen size occurred. The erythrocyte count returned to . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Third (New York University) Medical Service (Dr. Milton B. Rosenbluth, Director), Goldwater Memorial Hospital, Welfare Island.

Footnotes
Read before the Society for the Study of Blood at the New York Academy of Medicine, May 23, 1950.

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