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A Compound with Nitrogen-Mustard-like Activity Suitable for Oral and Intravenous Use

D. A. KARNOFSKY, M.D.; J. H. BURCHENAL, M.D.; G. C. ARMISTEAD, Jr., M.D.; C. M. SOUTHAM, M.D.; J. L. BERNSTEIN, M.D.; L. F. CRAVER, M.D.; C. P. RHOADS, M.D.

AMA Arch Intern Med. 1951;87(4):477-516.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE NITROGEN mustards were introduced into medical practice in 1946 for the palliative treatment of the lymphomas, leukemias and other types of neoplastic disease.¹ The most commonly administered nitrogen mustard is methyl-bis (2-chloroethyl) amine hydrochloride (HN2), and, since 1946, much experience has been gained from its use throughout the world.² This nitrogen mustard has found a useful place as a temporary palliative agent in the management of certain types and stages of neoplastic disease. It must be injected intravenously, and it frequently produces severe nausea and vomiting; consequently, its administration, in most cases, has been regarded as a hospital procedure. Extravasation of the injected solution will produce a prolonged and painful local reaction, and, in patients receiving repeated courses of treatment, venous thromboses and difficulty in finding suitable veins for injection may occur. The dosage must be carefully controlled, since an excessive dose will produce serious, prolonged . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Chemotherapy Service, Memorial Center for Cancer and Allied Diseases.

Footnotes
Triethylene melamine was supplied in tablet form by Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y.

This study was aided by the American Cancer Society, the National Cancer Institute of the United States Public Health Service, the Damon Runyon Memorial Fund for Cancer Research and the Babe Ruth Cancer Fund of the American Cancer Society.

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