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MANSON MEADS, M.D.; WALLACE P. ROWE, M.D.; NANCY M. HASLAM, B.S.

AMA Arch Intern Med. 1951;87(4):533-540.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE BACTERIAL flora of the normal nasopharynx may be altered significantly during the therapeutic administration of sulfadiazine,¹ penicillin² or streptomycin.³ Usually these changes are specific and selective, so that species of organisms which are highly susceptible to the drug are eliminated rapidly. More resistant groups of bacteria, which may be present in small numbers before therapy or may enter after therapy is begun, then multiply and become the predominant organisms during the first week of treatment. If these relatively drug-fast organisms are pathogenic, they may initiate a new bacterial infection in the patient during the course of treatment for the primary disease.⁴ Furthermore, these strains may be transmitted to others, causing infections that require different antibacterial drugs for treatment.⁵

Studies of the effect of aureomycin on the normal flora of the body have been limited to the micro-organisms in the gastrointestinal⁶ and genital tracts.⁷ Collins, Gocke and Finland,⁸ . . . [Full Text PDF of this Article]

Author Affiliations
WINSTON-SALEM, N. C.

From the Department of Internal Medicine of the Bowman Gray School of Medicine of Wake Forest College.

Footnotes
This investigation was supported (in part) by a research grant from the National Institutes of Health, United States Public Health Service.

The aureomycin and penicillin used in this study were supplied by Lederle Laboratories Division. American Cyanamid Company Pearl River. N. Y.

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