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J. A. ROBERTSON, M.B., M.R.C.P.; C. H. GRAY, M.D., M.Sc.; A. H. BAYNES, M.B., M.R.C.P.

AMA Arch Intern Med. 1951;87(4):570-582.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE RECOGNITION of a possibly specific renal lesion developing in treated diabetics is due to Kimmelstiel and Wilson.¹ They observed at autopsy a hyalinization of the intercapillary connective tissue of the glomeruli in seven diabetic patients who during life had shown evidence of renal dysfunction. This finding has been fully confirmed by a number of American workers and in this country by Gauld, Stalker and Lyall² and Hall.³

The clinical syndrome associated during life with the specific kidney lesion comprises hypertension, albuminuria and retinopathy; edema is a less constant finding. Death usually occurs either from a cardiovascular accident or from uremia. Most writers on this subject⁴ agree that the presence of the lesion at autopsy may be anticipated during life with a fair degree of certainty if the above clinical syndrome is noted in a patient with long-standing diabetes and in whom there is no previous . . . [Full Text PDF of this Article]

Author Affiliations
LONDON, ENGLAND

From the Diabetic Department, King's College Hospital and the Department of Chemical Pathology, King's College Hospital Medical School.

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