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Establishment of Renal Glycosuria

HARRIET DUSTAN, M.D.; A. C. CORCORAN, M.D.; ROBERT D. TAYLOR, M.D.; IRVINE H. PAGE, M.D.

AMA Arch Intern Med. 1951;87(5):627-635.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TREATMENT of normotensive patients with cortisone or pituitary adrenocorticotropic hormone (ACTH) has sometimes resulted in definite increases of arterial pressure.¹ In a hypertensive patient with dermatomyositis, ACTH administration has induced a state resembling hypertensive encephalopathy.² A few patients with hypertension have been described as showing some decrease in pressure after treatment with cortisone, so that it has been suggested that cortisone is. paradoxically, sometimes antipressor.³

Experimentally, many of the pathological changes elicited by use of desoxycorticosterone in rats are inhibited or reversed by treatment with adrenal cortex extracts or with ACTH.⁴ These lesions include an arterial disease which is similar to that observed in human beings suffering from severe hypertension.⁵ Thus, quite apart from the possible antipressor effects of cortisone or ACTH, there is a basis for supposing that they might favorably influence hypertensive vascular disease as such.

Our purpose here is to record effects . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Research Division and the Frank E. Bunts Educational Institute. Cleveland Clinic Foundation.

Footnotes
Dr. Dustan is a United States Public Health Service Postdoctorate Research Fellow.

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