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DONALD S. LITTMAN, M.D.; ROBERT H. STOCKDALE, M.D.; GEORGE R. WILLIAMSON, M.D.

AMA Arch Intern Med. 1951;87(5):707-712.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE REPORTED success of Lewin and Wassén¹ in the treatment of rheumatoid arthritis with desoxycorticosterone acetate (DCA) and ascorbic acid indicates the importance of adequate studies to evaluate this therapy on an objective basis. Practically all the subsequent reports,² which appeared in rapid succession after the original publication, were of a clinical nature with little objective evidence. In most of these reports the period of observation was much too short, considering the variability and chronicity of the disease.

The program of study in the present investigation included the following: (1) administration of a low sodium diet; (2) careful and frequent clinical evaluations; (3) substitution of placebos at varying intervals without the knowledge of the participating physicians; (4) daily record of body weight; (5) frequent blood pressure determinations; (6) roentgenograms of heart and lungs; (7) electrocardiograms; (8) complete blood counts; (9) total circulating eosinophil count before (control) and four . . . [Full Text PDF of this Article]

Author Affiliations
ASPINWALL, PA.

From the Medical Service, Veterans Administration Hospital, Aspinwall, Pa., and the University of Pittsburgh School of Medicine.

Footnotes
Drs. Littman and Stockdale are residents in internal medicine, and Dr. Williamson is attending in internal medicine, Veterans Administration Hospital.

Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

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