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Effects in Thirty-Four Patients with Decompensated Hepatic Cirrhosis

JOSEPH POST, M.D.; JEROME V. ROSE, M.D.; SEYMOUR M. SHORE, M.D.

AMA Arch Intern Med. 1951;87(6):775-788.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

JANEWAY and his associates¹ in 1944 administered human albumin intravenously to two patients with hepatic cirrhosis, ascites and hypoalbuminemia and noted temporary improvement with control of ascites. Since that time, conflicting reports have appeared concerning the effects of human albumin in treatment of decompensated hepatic cirrhosis.² The present study is concerned with the effects of intravenously administered salt-poor human albumin on the clinical courses of 34 patients, critically ill with cirrhosis of the liver, hypoalbuminemia and ascites. The substance was given in amounts sufficient to maintain a normal serum albumin concentration for extended periods. The results indicate that human albumin has a place in the therapy of such patients.

METHODS

A. Techniques of Study.

—All patients were kept in bed until there was evidence of continuing clinical improvement. The dietary regimen was as follows: 140 Gm. of protein, 340 Gm. of carbohydrate and 110 Gm. of fat were . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Medical Service of the Veterans Administration Hospital, Bronx, New York.

Footnotes
The American National Red Cross supplied the salt-poor albumin used in this study.

A preliminary report of this investigation was presented at the Forty-First Annual Meeting of the American Society for Clinical Investigation, Atlantic City, N. J., May 2, 1949 (J. Clin. Invest. 28:804, 1949).

Reviewed by the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are a result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

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