This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Observations on Three Families, with a Related Study of Bone Marrow Activity

HENRY E. HAMILTON, M.D.; WILLIS M. FOWLER, M.D.

AMA Arch Intern Med. 1951;87(6):825-834.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE INFORMATION acquired during the past 25 years concerning that form of anemia which was described by Cooley and Lee in 1925¹ has led to a better understanding of the disorder. This type of anemia was separated from the heterogenous symptom complex known as von Jaksch's anemia, or infantile pseudoleukemia, and was recognized as a distinct disease entity. The early papers by Cooley² described the condition as being characterized by a hypochromic microcytic anemia with many distorted erythrocytes which were usually resistant to hemolysis by hypotonic saline solution. Large numbers of nucleated erythrocytes in the normoblastic stage of development were encountered in the peripheral blood. Splenomegaly, episodes of jaundice and roentgenologic evidence of bone involvement were prominent features. The disease was usually seen in children of southern European parentage—Greek, Syrian or Italian peoples—though it has been reported from many other races over the world.³ The disease described . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Department of Internal Medicine, State University of Iowa, University Hospitals.

Footnotes
This study was supported by the Trust Fund of the Department of Internal Medicine.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?