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Morphologic Changes

WARD M. O'DONNELL, M.D.; STEFAN S. FAJANS, M.D.; JACK G. WEINBAUM, M.D.

AMA Arch Intern Med. 1951;88(1):28-35.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE INCREASING availability of pituitary adrenocorticotropic hormone (ACTH) and cortisone for clinical use has afforded us the opportunity to examine the adrenal glands of patients who had received these preparations prior to death. The possibility of finding structural changes which might be interpreted as a morphologic expression of functional stimulation or depression of the adrenal cortex made this study of interest. In addition, information might be obtained through which alterations in the adrenal glands of man could be compared with the known morphologic patterns in the adrenal cortices of animals under varying experimental conditions.

To appreciate the morphologic changes in the adrenal glands of patients studied in this series, it is necessary to review briefly the normal histologic pattern of lipid deposition in the human adrenal cortex. The greatest concentration of sudanophilic material is usually seen in the outer portion of the zona fasciculata, with a smaller amount in the . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

From the Department of Pathology (Drs. O'Donnell and Weinbaum) and the Department of Internal Medicine (Dr. Fajans), University of Michigan.

Footnotes
The work of Dr. Fajans was done during the tenure of a Life Insurance Medical Research Fellowship.

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