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Effect of Cortisone and ACTH

PHILIP W. RUSSELL, M.D.; JOHN R. HASERICK, M.D.; EDWARD M. ZUCKER, M.D.

AMA Arch Intern Med. 1951;88(1):78-92.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DISCOVERY of the L. E. (lupus erythematosus) phenomenon¹ in vivo² and in vitro³ has provided accurate diagnostic procedures for acute disseminated lupus erythematosus. These tests have given consistently positive reactions in typical cases of lupus. Moreover, they have indicated that the disease may exist for varying lengths of time in previously unrecognized forms before entering into the final, familiar clinical picture. The present study was prompted by the observation of protracted grand mal epileptic attacks in six of 23 lupus patients with positive L. E. test reactions. In brief, it is our contention that any patient with epilepsy and rheumatoid arthritis may have systemic⁴ lupus erythematosus.

The association of convulsive seizures with lupus erythematosus has been noted in many case reports, though no specific reference devoted to a correlation of the two entities has been found in the literature. To our knowledge electroencephalographic evidence of . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

Footnotes
This investigation was supported (in part) by a research grant from the National Institutes of Health, United States Public Health Service.

Dr. Russell was formerly Fellow in Medicine, Cleveland Clinic. His present address is Wichita Clinic, Wichita, Kan. Dr. Haserick and Dr. Zucker are from the Cleveland Clinic and the Frank E. Bunts Educational Institute.

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