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M. M. WINTROBE, M.D.; G. E. CARTWRIGHT, M.D.; J. G. PALMER, M.D.; W. J. KUHNS, M.D.; L. T. SAMUELS, Ph.D.

AMA Arch Intern Med. 1951;88(3):310-336.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SINCE the discovery that corticotrophin (ACTH) and cortisone exert beneficial effects on a wide variety of disease processes which had not been considered previously to be primarily hormonal in nature, a number of patients with disorders of the blood have been treated with these agents. This report describes our own studies in 40 cases. A preliminary report of the observations on 24 of these cases has been published.¹ It is now well known that lymphopenia and neutrophilia develop in experimental animals² and in man³ after administration of corticotrophin. The reduction in circulating eosinophils which follows administration of corticotrophin has been used as a test for adrenal-cortical insufficiency.⁴ Alterations have also been produced by corticotrophin and cortisone in various disease processes involving the leucocytes. Thus, improvement after corticotrophin therapy has been seen in a number of cases of acute leukemia, with "complete" temporary remissions in some. Improvement . . . [Full Text PDF of this Article]

Author Affiliations
SALT LAKE CITY

From the Departments of Medicine and Biochemistry, College of Medicine, University of Utah.

Footnotes
Dr. Palmer is a Fellow of the American Cancer Society.

Dr. Kuhns is a Fellow of the United States Public Health Service.

These studies were aided by grants from the United States Public Health Service and the Damon Runyon Memorial Fund for Cancer Research.

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