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II. Observations on the Urinary Protein

EDWARD C. PERSIKE, M.D.

AMA Arch Intern Med. 1951;88(3):346-349.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ADDIS has described¹ the clinical course of a supposed disorder of plasma protein metabolism, frequently cyclic, which is characterized initially by abnormal formation of plasma protein and proteinuria, following which a degenerative type of renal lesion develops, the plasma protein concentration falls and edema appears. When the patient he first described^1a was well, the plasma protein electrophoretic pattern was not unusual. The protein from both blood and urine produced an abnormal pattern, however, when the above noted findings were present. At pH 7.7 the fraction which had the mobility of serum albumin was split in two.² The hypothesis was advanced that the primary defect in this syndrome is both quantitative and qualitative, with a reduction in the rate of plasma protein formation and a production of abnormal protein molecules. It is supposed that the proteinuria occurs because of a structural defect in the plasma protein molecules, and . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Department of Medicine, Stanford University School of Medicine.

Footnotes
These experiments were aided by a grant from the Columbia Foundation.

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