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ORAL USE OF CATION-EXCHANGE RESINS IN TREATMENT OF EDEMA
KENDALL EMERSON, Jr., M.D.;
STANLEY S. KAHN, M.D.;
JOHN W. VESTER, M.D.;
K. DEXTER NELSON, M.D.
AMA Arch Intern Med. 1951;88(5):605-617.
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THE SUCCESSFUL use of cation-exchange resins in the treatment of edema in man first suggested by Dock1 has now been reported by several investigators.2 Their use in the form of an enema for the treatment of potassium intoxication has also been reported by Elkinton and associates.3 An excellent discussion of the mechanism of action and the many and varied uses of ion-exchange resins may be found in a monograph edited by Nachod.4
The purpose of the present report is to describe the use of cation-exchange resins for the removal of sodium via the intestinal tract in the treatment of edematous states and to define the advantages and limitations of this form of therapy. Both acute balance experiments showing the quantitative removal of cations in the feces and studies of the effects of prolonged administration (three months to two years) of these resins will be reported.
MATERIAL
. . . [Full Text PDF of this Article]
Author Affiliations
BOSTON
From the Department of Medicine, Harvard Medical School, and the Medical Clinic, Peter Bent Brigham Hospital.
Footnotes
Dr. Emerson is Assistant Professor of Medicine, Harvard Medical School, and Senior Associate in Medicine, Peter Bent Brigham Hospital.
Dr. Kahn is United States Public Health Fellow.
Dr. Vester and Dr. Nelson are Assistants in Medicine, Peter Bent Brigham Hospital and Harvard Medical School.
This study was aided by a grant from the Smith, Kline & French Laboratories, Philadelphia 1.
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