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Review of Eighty-Nine Cases with Particular Reference to the Differentiation and Treatment of Acute (Self-Limited) and Chronic Types

ERWIN O. HIRSCH, M.D.; WILLIAM DAMESHEK, M.D.

AMA Arch Intern Med. 1951;88(6):701-728.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE CONDITION first recorded by Werlhof¹ and now known as "idiopathic," "essential," or "primary" thrombocytopenic purpura is usually described as a disease of unknown causation characterized by such hemorrhagic manifestations as purpura, bleeding from the mucous membranes, thrombocytopenia, a prolonged bleeding time, and failure of the clot to retract, in the absence of an underlying disease known to lead to thrombocytopenia.

In the many reviews published during the last 15 years the diagnostic features mentioned above have always been emphasized, together with the often dramatic results following splenectomy.² On the other hand, the natural course of the disease has been discussed in relatively few publications,³ in spite of the fact that the tendency to remissions and relapses is well recognized. Although chronic mild hemorrhagic symptoms are mentioned, one usually gains the impression that while one attack of thrombocytopenic purpura leaves the patient subject to further attacks the . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

Footnotes
Dr. Hirsch was formerly Fellow in Hematology, New England Center Hospital. He is presently at Peter Bent Brigham Hospital.

Dr. Dameshek is Director, Blood Research Laboratory, New England Center Hospital.

From the Blood Research Laboratory of the J. H. Pratt and New England Center Hospitals and the Department of Medicine, Tufts College Medical School. This work was aided by grants from the Charlton Fund and the C. H. Hood Dairy Foundation.

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