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NORMAN B. McCULLOUGH, Ph.D., M.D.; C. WESLEY EISELE, M.D.

AMA Arch Intern Med. 1951;88(6):793-802.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HEPATIC involvement in brucellosis has been recognized since the original description of undulant fever as a distinct disease entity by Marston in 1859.¹ It was noted by Hughes (1897).² Cantaloube (1911)³ stressed the frequency of liver involvement, reporting hepatomegaly in 10% of his cases. Centrolobular necrosis (Hardy and others, 1931 )⁴ of the liver in human brucellosis and even extensive destruction of liver parenchyma (Wohlwill, 1932)⁵ have been described.

The granulomatous nature of brucellosis has been well known since the description of such lesions in the experimentally infected guinea pig by Fabyan (1912)⁶ and later Jaffé ( 1922)⁷ and other workers. Löffler and von Albertini (1930)⁸ described such lesions in human material, and later von Albertini and Lieberherr (1937)⁹ reviewed the pathology of human brucellosis and presented in detail the changes occurring in the liver and spleen.

Although but few English references have appeared, in the . . . [Full Text PDF of this Article]

Author Affiliations
BETHESDA, MD.; CHICAGO

From the Department of Medicine, University of Chicago (Dr. McCullough and Dr. Eisele), and from the Federal Security Agency, Public Health Service, National Institutes of Health, Microbiological Institute, Bethesda, Md. (Dr. McCullough).

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